Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria

作者：Gutierrez Perez Areli; Cortes Rojo Christian; Noriega Cisneros Ruth; Calderon Cortes Elizabeth; Manzo Avalos Salvador; Clemente Guerrero Monica; Godinez Hernandez Daniel; Boldogh Istvan; Saavedra Molina Alfredo^*

来源：Journal of Bioenergetics and Biomembranes, 2011, 43(2): 101-107.

DOI：10.1007/s10863-011-9349-4

• Cardioprotection
• Resveratrol
• Mitochondria
• Oxidative stress
• Calcium-overload

Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe(2+) + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.

• 出版日期2011-4