Novel crown-ether-methylenedipho-sphonotetrathioate hybrids as Zn(II) chelators

作者：Meltzer Diana; Gottlieb Hugo E; Amir Aviran; Shimon Linda J W; Fischer Bilha^*

来源：Dalton Transactions, 2015, 44(48): 21073-21080.

DOI：10.1039/c5dt03935e

Hybrids of methylenediphosphonotetrathioate and crown-ether (MDPT-CE) were synthesized forming 7-, 8-, 9-, 10- and 13-membered rings. Both 7- and 13-membered ring-containing compounds were found to be highly stable to air-oxidation for at least four weeks. These hybrids bind Zn(II) by both MDPT and CE moieties, forming a 2 : 1 L : Zn(II) complex. Interestingly, the 13-membered ring MDPT-CE showing a high affinity to Zn(II) (K-a 3 +/- 0.5 x 10(6) mol(-2) L-2) does not bind Li(I) or Na(I). The 13-Membered MDPT-CE hybrid is a promising water-soluble, air-stable, high-affinity Zn(II)-chelator, exhibiting selectivity to Zn(II) vs. Mg(II), Na(I), and Li(I).

• 出版日期2015