Deterioration in Renal Function Is Associated With Increased Arterial Stiffness

作者：Elias Merrill F^*; Davey Adam; Dore Gregory A; Gillespie Avrum; Abhayaratna Walter P; Robbins Michael A

来源：American Journal of Hypertension, 2014, 27(2): 207-214.

DOI：10.1093/ajh/hpt179

• blood pressure
• cardiovascular disease
• chronic kidney disease
• estimated glomerular filtration rate
• hypertension
• pulse wave velocity
• renal disease

Higher levels of baseline pulse wave velocity (PWV) have been associated with longitudinal decline in renal function in patients with kidney disease. We examined longitudinal decline in renal function in relation to levels of PWV. We hypothesized that longitudinal decline in renal function in a community-based, nonclinic sample would be associated with higher levels of PWV. %26lt;br%26gt;We conducted a 45 year longitudinal study with 482 community-living individuals free from acute stroke, dementia, and end-stage renal disease (mean age 60.9 years; 59% women; 93.2% white; 10% with diabetes mellitus; mean estimated glomerular filtration rate (eGFR) 79.2ml/min/1.73 m(2)). Multiple linear regression analyses were used to examine the association between changes in renal eGFR and serum creatinine) from baseline to follow-up and PWV levels at follow-up, the outcome measure. Regression coefficients were adjusted for age, sex, education, race/ethnicity, weight, activity level, mean arterial pressure, treatment of hypertension, and cardiovascular risk factors. %26lt;br%26gt;With adjustment for covariables, decline in renal function was associated with higher levels of PWV over a mean follow-up of 4.68 years. %26lt;br%26gt;Decline in renal functioning from baseline levels measured 45 years before measurement of PWV is related to higher levels of PWV in a community sample.

• 出版日期2014-2