Clinical efficacy of denosumab versus bisphosphonates for the prevention of bone complications: implications for nursing

作者：Campbell Baird Cynthia^*; Harrelson Stacey; Frey Georgette; Balakumaran Arun

来源：Supportive Care in Cancer, 2015, 23(12): 3625-3632.

DOI：10.1007/s00520-015-2887-2

• Antiresorptive
• Bisphosphonates
• Bone metastases
• Denosumab
• Skeletal-related events

Antiresorptive therapies are used for the prevention of skeletal-related events (SREs) associated with metastatic bone disease related to breast cancer, prostate cancer, and other solid tumors. This review highlights the central role of nurses in supporting and educating advanced cancer patients regarding the consequences of bone metastases and SREs, including therapy management options. Contemporary clinical journals reporting evidence-based studies were reviewed. SREs associated with bone metastases can significantly impact the quality of life of advanced cancer patients. Denosumab therapy, an advancement in antiresorptive treatments, significantly prevents and delays the time to develop SREs. In the multifaceted approach required for successful and consistent management of SREs associated with bone metastases, antiresorptive therapies can play a central role in maintaining the functional independence of patients through the prevention of debilitating SREs, thereby preserving quality of life.

• 出版日期2015-12