Antioxidant therapy for management of oxidative stress induced hypertension

作者：Ahmad Khalil Ali; Yuan Dai Yuan; Nawaz Waqas; Ze Hong; Zhuo Chen Xue; Talal Bashar; Taleb Abdoh; Mais Enos; Ding Qilong^*

来源：Free Radical Research, 2017, 51(4): 428-438.

DOI：10.1080/10715762.2017.1322205

• Antioxidant therapy
• oxidative stress
• hypertension
• endothelial dysfunction

Hypertension is considered as the most common risk factor for cardiovascular diseases, also is regarded as a leading cause of the mortality and morbidity worldwide. The mechanisms underlying the pathological process of hypertension are not completely explained. However, there is growing evidence that increased oxidative stress plays an important role in the pathophysiology of hypertension. Several preclinical studies and clinical trials have indicated that antioxidant therapy is important for management of hypertension, using antioxidants compounds such as alpha tocopherol (Vit E) and ascorbic acid (Vit C), polyphenols with others and some antihypertensive drugs that are now in clinical use (e.g. ACEIs, ARBs, novel B-blockers, dihydropyridine CCBs) which have antioxidative pleiotropic effects. The purpose of this review is to highlight the importance of antioxidant therapy for management of oxidative stress induced hypertension. Furthermore, we review the current knowledge in the oxidative stress and its significance in hypertension.

• 出版日期2017
• 单位中国药科大学