Association between variable number tandem repeats within the 3 ' flanking region of the interleukin-6 gene and systemic lupus erythematosus in Korean patients

作者：Jeon J Y; Kim H A; Kim S H; Suh C H^*

来源：Lupus, 2011, 20(11): 1161-1165.

DOI：10.1177/0961203311405704

• interleukin-6
• systemic lupus erythematosus
• variable number tandem repeat

Variable number tandem repeat (VNTR) polymorphism located in the 3' flanking region of the interleukin-6 (IL-6) gene was examined in Koreans with systemic lupus erythematosus (SLE). We identified 15 VNTR alleles (K1 to K15) in the 3' flanking region by Genescan analysis. The VNTR K8 allele, a 648-base pair (bp) allele, was most commonly found in Koreans, being present in 74.8% of the SLE patients and 70.3% of the normal controls. The VNTR K9 (642 bp) allele was associated with susceptibility to SLE. In addition, the VNTR K9 was significantly associated with leukopenia (p=0.048), thrombocytopenia (p=0.020), and elevated C-reactive protein (p=0.019). These data suggest that the VNTR K9 in the 3' flanking region of the IL-6 gene may be associated with disease susceptibility and the clinical phenotypes of SLE. Lupus (2011) 20, 1161-1165.

• 出版日期2011-10