Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people

作者：Liang, R.; Yan, X. X.; Lin, Y.; Li, Q.; Yuan, C. L.; Liu, Z. H.; Li, Y. Q.^*

来源：Genetics and Molecular Research, 2016, 15(2): 15028093.

DOI：10.4238/gmr.15028093

• Hepatocellular carcinoma
• Disease-free survival
• COX-2-1195G > A (rs689466) polymorphism
• COX-2-765G > C (rs20417) polymorphism
• Independent influence factor

Cyclooxygenase-2 (COX-2) influences carcinogenesis through regulation of angiogenesis, apoptosis, cytokine expression, and immune response suppression. It has been well established that COX-2 is overexpressed in a variety of human cancers, such as hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the association between COX-2 polymorphisms and prognosis of HCC. We genotyped 200 HCC patients of Chinese Han descent for COX2 gene polymorphisms (-765G>C and - 1195G>A) using PCR-RFLP. Data were statistically analyzed using the Kaplan-Meier method and the Cox's proportional hazard regression model. We found that patients with the COX-2 - 1195AG and -1195AG + AA genotypes demonstrated significantly decreased disease-free survival (DFS) as compared with those carrying the - 1195GG genotype (P < 0.05). However, the COX2 -765G>C polymorphism was not associated with DFS (P > 0.05). Moreover, by Cox regression analysis, blood alpha fetoprotein <= 400 ng/mL before the operation and the -1195G>A polymorphism were found to be of prognostic significance (P < 0.05), while the -765G>C polymorphism was not (P > 0.05). In summary, post-operation progression of HCC is more likely to occur in patients with the -1195AG genotype and the A allele. On the other hand, the -765G>C polymorphism is not an independent influence factor of HCC prognosis.

• 出版日期2016
• 单位广西医科大学