Aerobic Training Suppresses Exercise-Induced Lipid Peroxidation and Inflammation in Overweight/Obese Adolescent Girls

作者：Youssef Hala; Groussard Carole^*; Lemoine Morel Sophie; Pincemail Joel; Jacob Christophe; Moussa Elie; Fazah Abdallah; Cillard Josiane; Pineau Jean Claude; Delamarche Arlette

来源：Pediatric Exercise Science, 2015, 27(1): 67-76.

DOI：10.1123/pes.2014-0008

• aerobic training
• exercise
• lipid peroxidation
• inflammation
• obesity
• adolescent girls

This study aimed to determine whether aerobic training could reduce lipid peroxidation and inflammation at rest and after maximal exhaustive exercise in overweight/obese adolescent girls. Thirty-nine adolescent girls (14-19 years old) were classified as nonobese or overweight/obese and then randomly assigned to either the nontrained or trained group (12-week multivariate aerobic training program). Measurements at the beginning of the experiment and at 3 months consisted of body composition, aerobic fitness (VO2(peak)) and the following blood assays: pre-and postexercise lipid peroxidation (15F(2)a-isoprostanes [F-2-Isop], lipid hydroperoxide [ROOK oxidized LDL [ox-LDL]) and inflammation (myeloperoxidase [MPO]) markers. In the overweight/ obese group, the training program significantly increased their fat-free mass (FFM) and decreased their percentage of fat mass (%FM) and hip circumference but did not modify their VO2(peak). Conversely, in the nontrained overweight/obese group, weight and %FM increased, and VO2peak decreased, during the same period. Training also prevented exercise-induced lipid peroxidation and/or inflammation in overweight/obese girls (F-2-Isop, ROOH, ox-LDL, MPO). In addition, in the trained overweight/obese group, exercise-induced changes in ROOH, ox-LDL and F-2-Isop were correlated with improvements in anthropometric parameters (waist-to-hip ratio, %FM and FFM). In conclusion aerobic training increased tolerance to exercise-induced oxidative stress in overweight/obese adolescent girls partly as a result of improved body composition.

• 出版日期2015-2