A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones

作者：Ban, Shu-rong^*; Zhu, Xi-xia; Zhang, Zhi-ping; Li, Qing-shan

来源：Bioorganic & Medicinal Chemistry Letters, 2014, 24(11): 2517-2520.

DOI：10.1016/j.bmcl.2014.04.005

• Benzoylthiourea-pyrrolidine
• Enantioselective
• Michael addition
• Ketones
• Chalcones

A benzoylthiourea-pyrrolidine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding products were obtained in high yields with high level of diastereoselectivities (up to 99:1 dr) and high level of enantioselectivities (up to 94% ee) under mild conditions.

• 出版日期2014-6-1
• 单位McGill; 山西医科大学