A case of premature ovarian failure (POF) in a 31-year-old woman with a 47,XXX karyotype

作者：Skalba Piotr^*; Cygal Anna; Gierzynska Zuzanna

来源：Endokrynologia Polska, 2010, 61(2): 217-219.

• premature ovanian failure
• polisomy 47,XXX
• secondary amenorrhoea

A case of POF in a 31-year-old woman with karyotype 47,XXX. The aim of the study was to discuss a case of POF in a 31-year-old patient with polysomy 47,XXX. The described karyotype is not usually associated with this characteristic physical phenotype. In some rare cases, menstrual disorders, sterility, secondary amenorrhoea, premature menopause, and low intelligence are found. Our observations revealed the necessity for cytogenetic examination in all women at reproductive age with symptoms of premature ovarian failure. According to the data found in literature, patients with POF and karyotype disorders belong to the risk group of premature death, mostly for cardiological reasons. Raising patient awareness about the risk may have a positive effect on quality of life and regularity of check-ups. (Pol J Endocrinol 2010; 61 (2): 217-219)

• 出版日期2010-4