Asymmetric Synthesis of Monofluorinated 1-Amino-1,2-dihydronaphthalene and 1,3-Amino Alcohol Derivatives

作者：Lazaro Ruben; Roman Raquel; Sedgwick Daniel M; Haufe Guenter; Barrio Pablo^*; Fustero Santos^*

来源：Organic Letters, 2016, 18(5): 948-951.

DOI：10.1021/acs.orglett.5b03671

Enantioenriched 1-amino-4-fluoro-1,2-dihydronaphthalene derivatives are accessed-via two complementary synthetic strategies. The careful optimization of the reaction conditions required for the elimination step in one route has allowed both the identification of an anchimerically assisted reaction pathway and, more importantly, access to a divergent reaction pathway toward fluorinated 1,3-amino alcohols from a common intermediate just by adjusting the number of equivalents of base used.

• 出版日期2016-3-4