Applicability of chemically modified capillaries in chiral capillary electrophoresis for methamphetamine profiling

作者：Iwata Yuko T^*; Mikuma Toshiyasu; Kuwayama Kenji; Tsujikawa Kenji; Miyaguchi Hajime; Kanamori Tatsuyuki; Inoue Hiroyuki

来源：Forensic Science International, 2013, 226(1-3): 235-239.

DOI：10.1016/j.forsciint.2013.01.033

• Amphetamine-type stimulants
• Chiral separation
• Drug profiling
• Capillary electrophoresis
• Sulfated cyclodextrin
• Chemically modified capillary

We examined the applicability of chemically modified capillaries on the chiral capillary electrophoresis of essential compounds for methamphetamine (MA) profiling (MA, amphetamine, ephedrine, pseudoephedrine, norephedrine, and norpseudoephedrine) using highly sulfated gamma-cyclodextrin as a chiral selector. Four types of chemically modified capillaries, namely, FunCap-CE/ Type D (possessing diol groups), Type A (amino groups), Type C (carboxyl groups), and Type S (sulfate groups), were evaluated. Repeatability, speed, and good chiral resolution sufficient for routine MA profiling were achieved with the Type S capillary.

• 出版日期2013-3-10