An ovine in vivo framework for tracheobronchial stent analysis

作者：McGrath Donnacha J^*; Thiebes Anja Lena; Cornelissen Christian G; O'Shea Mary B; O'Brien Barry; Jockenhoevel Stefan; Bruzzi Mark; McHugh Peter E^*

来源：Biomechanics and Modeling in Mechanobiology, 2017, 16(5): 1535-1553.

DOI：10.1007/s10237-017-0904-8

• Biomechanical
• Lung
• Tracheobronchial
• Nitinol
• Stenting
• Finite element method

Tracheobronchial stents are most commonly used to restore patency to airways stenosed by tumour growth. Currently all tracheobronchial stents are associated with complications such as stent migration, granulation tissue formation, mucous plugging and stent strut fracture. The present work develops a computational framework to evaluate tracheobronchial stent designs in vivo. Pressurised computed tomography is used to create a biomechanical lung model which takes into account the in vivo stress state, global lung deformation and local loading from pressure variation. Stent interaction with the airway is then evaluated for a number of loading conditions including normal breathing, coughing and ventilation. Results of the analysis indicate that three of the major complications associated with tracheobronchial stents can potentially be analysed with this framework, which can be readily applied to the human case. Airway deformation caused by lung motion is shown to have a significant effect on stent mechanical performance, including implications for stent migration, granulation formation and stent fracture.

• 出版日期2017-10