Multidrug-Resistant Tuberculosis, People's Republic of China, 2007-2009

作者：He, Guang Xue^*; Wang, Hai Ying; Borgdorff, Martien W.; van Soolingen, Dick; van der Werf, Marieke J.; Liu, Zhi Min; Li, Xue Zheng; Guo, Hui; Zhao, Yan Lin; Varma, Jay K.; Tostado, Christopher P.; van den Hof, Susan

来源：Emerging Infectious Diseases, 2011, 17(10): 1831-1838.

DOI：10.3201/eid1710.110546

• MYCOBACTERIUM-TUBERCULOSIS
• DRUG-RESISTANT
• NOSOCOMIAL OUTBREAK
• BEIJING/W STRAINS
• COMPLEX
• EPIDEMIOLOGY
• SURVEILLANCE
• TRANSMISSION
• EMERGENCE
• GENOTYPE

We conducted a case-control study to investigate risk factors for multidrug-resistant tuberculosis (MDR TB) in the People's Republic of China. Genotyping analysis was used to estimate the percentage of cases from recent transmission among 100 MDR TB case-patients hospitalized during April 2007-July 2009. Molecular subtyping of isolates showed that 41% of MDR TB strains clustered. Beijing genotype was found in 94% of the MDR TB isolates and 79% of the pan-susceptible isolates. In multivariate analysis, MDR TB was independently associated with Beijing genotype, retreatment for TB, symptoms lasting >= 3 months before first evaluation at the hospital, lack of health insurance, and being a farmer (vs. being a student). MDR TB was associated with Beijing genotype and lower socioeconomic status. A large percentage of MDR TB cases seemed to result from recent transmission. Early detection, effective treatment, and infection control measures for MDR TB are needed to reduce transmission.

• 出版日期2011-10
• 单位清华大学; 中国疾病预防控制中心