A NOVEL HYDRODYNAMIC FOCUSING MICRODEVICE FOR FLOW CYTOMETRY APPLICATIONS

作者：Vakilzadeh A H; Kamali R^*

来源：Iranian Journal of Science and Technology-Transactions of Mechanical Engineering, 2014, 38(M2): 361-373.

• 3D hydrodynamic focusing
• flow cytometry
• particle trajectory
• numerical investigation
• molecule detection

Hydrodynamic focusing is one of the most utilized techniques in microfluidics. Its applications have been employed in a wide variety of biological analyses including on-chip flow cytometry, single molecule detection, and laminar mixers. In the present study, a new hydrodynamic focusing microdevice for flow cytometry applications is presented and numerically investigated. In the proposed microdevice, the sample fluid is compressed both in vertical and horizontal directions simultaneously by radial sheath flows injected within flow cytometer through one ring. The microdevice configuration is optimized and effective parameters on stream distribution are investigated. In addition, in order to observe hydrodynamic focusing phenomena, particles trajectories are studied. Moreover, results of the proposed model are compared with the previous one in order to verify that the performance of the present model is more efficient.

• 出版日期2014-10