Acute toxicity and withdrawal syndromes related to gamma-hydroxybutyrate (GHB) and its analogues gamma-butyrolactone (GBL) and 1,4-butanediol(1,4-BD)(1)

作者：Wood David M^*; Brailsford Alan D; Dargan Paul I

来源：Drug Testing and Analysis, 2011, 3(7-8): 417-425.

DOI：10.1002/dta.292

• gamma-hydroxybutyrate
• gamma-butyrolactone
• 1,4-butanediol
• poisoning
• recreational drugs
• drugs of abuse
• dependency
• withdrawal

Gamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patterns and management of acute toxicity associated with their use; and the clinical patterns of presentation and management of chronic dependency associated with GHB and its analogues.

• 出版日期2011-8