An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition

作者：You Ling Feng; Hsung Richard P^*; Bedermann Aaron A; Kurdyumov Aleksey V; Tang Yu; Buchanan Grant S; Cole Kevin P

来源：Advanced Synthesis & Catalysis, 2008, 350(18): 2885-2891.

DOI：10.1002/adsc.200800552

• asymmetric Diels-Alder cycloaddition
• chromium(II)-salen catalyst
• intramolecular oxa-[3+3]annulation
• phomactin A
• Rawal's 1-amino-3-siloxy-1,3-butadiene

An enantioselective synthesis of the ABD ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.

• 出版日期2008-12