FGF Family: From Drug Development to Clinical Application

作者：Hui, Qi; Jin, Zi; Li, Xiaokun; Liu, Changxiao; Wang, Xiaojie^*

来源：International Journal of Molecular Sciences, 2018, 19(7): 1875.

DOI：10.3390/ijms19071875

• fibroblast growth factor
• wound healing
• metabolic regulation
• fibroblast growth factor receptor inhibitor
• drug development
• clinical application

Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment of burn and ulcer wounds are now available. The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose, and phosphate further extended the activity profile of this family. Here, the applications of recombinant FGFs for the treatment of wounds, diabetes, hypophosphatemia, the development of FGF receptor inhibitors as anti-neoplastic drugs, and the achievements of basic research and applications of FGFs in China are reviewed.

• 出版日期2018-7
• 单位温州医科大学; 天津药物研究院有限公司