A New Diterpenoid with a Rearranged Skeleton from Salvia prattii

作者:Kawabe, Hiroshi; Suzuki, Riyo; Hirota, Hiroshi; Matsuzaki, Keiichi; Gong, Xun; Ohsaki, Ayumi*
来源:Natural Product Communications, 2017, 12(8): 1177-1179.
DOI:10.1177/1934578x1701200807

摘要

A new diterpenoid with a rearranged skeleton, prattinin A (1), was isolated along with five known compounds (2-6) from the roots of Salvia prattii. The structure of 1 bearing a methyl group at the C-5 position was established by extensive spectroscopic analyses and the absolute configuration of 1 was elucidated by comparing the calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1, 3, 4, and 5 exhibited moderate or weak cytotoxicity against HL-60 and HeLa cell lines.

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