Agreement and Reliability of Fasted and Oral Glucose Tolerance Test-Derived Indices of Insulin Sensitivity and Beta Cell Function in Boys

作者：Cockcroft Emma Joanne; Williams Craig Anthony; Jackman Sarah Rebecca; Armstrong Neil; Barker Alan R^*

来源：International Journal of Sports Medicine, 2017, 38(6): 411-+.

DOI：10.1055/s-0043-104932

• insulin sensitivity
• youth
• type 2 diabetes

Assessment of plasma insulin and glucose outcomes is important in paediatric studies aimed at reducing future risk of type 2 diabetes and cardiovascular disease. The aims of this study are to determine the between-method agreement and the day-to-day reliability of fasting and oral glucose tolerance test (OGTT)-derived estimates of insulin sensitivity and beta-cell function in healthy boys. Fasting and OGTT assesments of insulin resistance and beta-cell function were performed on 28 boys (12.3 +/- 2.9 years). Measurements were repeated after 1 week (fasting, n = 28) and 1 day (OGTT, n = 8). Agreement between estimates of insulin resistance and beta-cell function was examined using Pearson's correlation coefficient. Reliability was assessed using change in the mean, Pearson's correlation coefficient, and typical error expressed as a coefficient of variation (CV). The Matsuda index was positively related with QUICKI (r = 0.88, P < 0.001) and negatively related to HOMA-IR (r = - 0.76, P < 0.001). The Cederholm index was not significantly related with fasting estimates of insulin resistance (all r < 0.40, P > 0.05). For reliability, QUICKI had the lowest CV % for the fasting (4.7 %) and the Cederholm index for the OGTT (6.4 %) estimates. The largest CV % was observed in fasting insulin (30.8 %) and insulinogenic index 30' (62.5 %). This study highlights differences in between-method agreement and day-to-day reliability for estimates of insulin resistance in youth. The low CV supports the use of the FGIR (fasting) and Cederholm (OGTT) indices in this population.

• 出版日期2017-6