Numerical analysis of micro- and nano-particle deposition in a realistic human upper airway

作者：Ghalati Pejman Farhadi; Keshavarzian Erfan; Abouali Omid^*; Faramarzi Abolhassan; Tu Jiyuan; Shakibafard Alireza

来源：Computers in Biology and Medicine, 2012, 42(1): 39-49.

DOI：10.1016/j.compbiomed.2011.10.005

• Human Upper Airway
• Micro-particle
• Nano-particle
• CFD

A computational model was developed for studying the flow field and particle deposition in a human upper airway system, including: nasal cavity, nasopharynx, oropharynx, larynx and trachea. A series of coronal CT scan images of a 24 year old woman was used to construct the 3D model. The Lagrangian and Eulerian approaches were used, respectively, to find the trajectories of micro-particles and concentration of nano-particles. The total and regional deposition fractions of micro/nanoparticles were evaluated and the major hot spots for the deposition of inhaled particles were found.

• 出版日期2012-1