A Functional Polymorphism on Chromosome 15q25 Associated with Survival of Early Stage Non-Small-Cell Lung Cancer

作者：Jin Guang; Bae Eun Young; Yang Enyue; Lee Eung Bae; Lee Won Kee; Choi Jin Eun; Jeon Hyo Sung; Yoo Seung Soo; Lee Shin Yup; Lee Jaehee; Cha Sung Ick; Kim Chang Ho; Cho Sukki; Jheon Sanghoon; Park Jae Yong^*

来源：Journal of Thoracic Oncology, 2012, 7(5): 808-814.

DOI：10.1097/JTO.0b013e31824c7d7c

• CHRNA3
• Polymorphism
• Non-small-cell lung cancer
• Survival

Introduction: The 15q25 region has been associated with lung-cancer risk and might also be associated with the prognosis of lung cancer. This study was conducted to determine the impact of a functional polymorphism in the CHRNA3 gene on chromosome 15q25 in the survival of patients with early-stage non-small-cell lung cancer (NSCLC). %26lt;br%26gt;Methods: Five hundred and eighty-three consecutive patients with surgically resected NSCLC were enrolled. The rs6495309C %26gt; T polymorphism in the promoter of the CHRNA3 gene was investigated. The association between genotype and overall survival (OS) and disease-free survival (DFS) was analyzed. %26lt;br%26gt;Results: Patients with the rs6495309 CT or TT genotype had a significantly better OS and DFS than the rs6495309 CC genotype (adjusted hazard ratio for OS = 0.56, 95% confidence interval = 0.41-0.75, p = 0.0001; and adjusted hazard ratio for DFS = 0.61, 95% confidence interval = 0.48-0.79, p = 0.0001). An association between the rs6495309C %26gt; T polymorphism and survival outcome was demonstrated in smokers and never-smokers, and in squamous-cell carcinomas and adenocarcinomas. %26lt;br%26gt;Conclusion: The CHRNA3 rs6495309C %26gt; T polymorphism may affect survival in patients with early-stage NSCLC. Analysis of the rs6495309C %26gt; T polymorphism can help identify patients at high risk of a poor disease outcome.

• 出版日期2012-5
• 单位延边大学