科研之友
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摘要
Purpose:To evaluate the safety and efficacy of real-time measurement of corneal epithelial thickness and investigate the distribution characteristics in a large normal-eye population using a clinically available spectral-domain anterior-segment optical coherence tomography (AS OCT) system.Methods:Corneal epithelial thickness distribution and topographic thickness variability were clinically investigated using AS OCT imaging in 373 patients with normal, healthy eyes. Descriptive statistics investigated 3 sets of subgroups, male (n = 171) and female (n = 202), younger (n = 194) and older (n = 179), right eyes (n = 195) and left eyes (n = 197).Results:Pupil center epithelial thickness repeatability was an average 0.88 0.71 m; a similar repeatability was noted for the superior, inferior, maximum, and minimum epithelial thickness. On average, the pupil center epithelial thickness was 53.28 +/- 3.34 m, superior 51.86 +/- 3.78 m, inferior 53.81 +/- 3.44 m, minimum 48.65 +/- 4.54 m, maximum 56.35 +/- 3.80 m, and topographic variability was 1.78 +/- 0.78 m. Small differences were noted between male (average center 54.10 +/- 3.34 m) and female (52.58 +/- 3.19 m) subjects. The topographic thickness variability seems to increase with age: younger group, 1.65 +/- 0.83 m; older group, 1.93 +/- 0.90 m (P = 0.173).Conclusions:We present a comprehensive investigation of corneal epithelial thickness distribution characteristics in a healthy, untreated human eye population by using in vivo, clinically available Fourier-domain AS OCT. The 3-dimensional epithelial maps reveal epithelial nonuniformity and provide a novel benchmark for future and comparative studies.
- 出版日期2013-11
