Pathway crosstalk analysis based on protein-protein network analysis in prostate cancer

作者：Wang, J. -M.; Wu, J. -T.; Sun, D. -K.; Zhang, P.; Wang, L.^*

来源：European Review for Medical and Pharmacological Sciences, 2012, 16(9): 1235-1242.

• Prostate cancer
• Protein-protein network
• Pathway crosstalk

BACKGROUND: Prostate cancer (PCa) is a highly prevalent disease in older men of the western world and overall greatly affects the quality of life of elderly people.
AIM: Understanding the mechanism of prostate cancer onset and metastasis is the key to treating this disease successfully and increasing survivability.
MATERIALS AND METHODS: In this study, we constructed crosstalk networks among prostate cancer (primary and metastatic) related pathways by integrating protein-protein interactions (PPI) and KEGG (Kyoto encyclopedia of genes and genomes) pathways information. Total 11 pathways crosstalk with each other in primary prostate cancer and 7 pathways crosstalk with each other in metastatic prostate cancer.
RESULTS: Among these pathways, Notch signaling pathway and chemokine signaling pathway were found regulate multiple processes during prostate cancer progression.
CONCLUSIONS: Results from these studies will provide the groundwork for a combination therapy approach targeting multiple pathways which will likely be more effective than targeting one pathway alone.

• 出版日期2012-9
• 单位山东大学; 烟台毓璜顶医院