Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer

作者：Akkiprik Mustafa; Feng Yumei; Wang Huamin; Chen Kexin; Hu Limei; Sahin Aysegul; Krishnamurthy Savitri; Ozer Ayse; Hao Xishan; Zhang Wei^*

来源：Breast Cancer Research, 2008, 10(4): 212.

DOI：10.1186/bcr2116

The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.

• 出版日期2008
• 单位天津医科大学