Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate

作者：Begum Haque Sakhina^*; Christy Marc; Ochoa Reparaz Javier; Nowak Elizabeth C; Mielcarz Daniel; Hague Azizul; Kasper Lloyd H

来源：Journal of Neuroimmunology, 2011, 232(1-2): 136-144.

DOI：10.1016/j.jneuroim.2010.10.031

• Glatiramer acetate
• Inflammation
• B cells
• CD19
• CD5

We recently showed that B cells reduce CNS inflammation in mice with experimental allergic encephalomyelitis (EAE). Here, we demonstrate that adoptively transferred CD5/CD19+ B cells protect against EAE severity. Furthermore, we show that glatiramer acetate (GA), a therapeutic for relapsing multiple sclerosis treatment, amplifies this effect. Transfer of GA-conditioned B cells leads to increased production of immunoregulatory cytokines and reduced CNS inflammation, as well as decreased expression of the chemokine receptor, CXCR5, and elevated BDNF expression in the CNS. Thus B cells can protect against EAE, and GA augments this effect in maintaining immune homeostasis and controlling EAE disease progression.

• 出版日期2011-3