A national series of 244 sinonasal cancers in Finland in 1990-2004

作者：Koivunen Petri; Makitie Antti A; Back Leif; Pukkila Matti; Laranne Jussi; Kinnunen Ilpo; Aitasalo Kalle; Grenman Reidar^*

来源：European Archives of Oto-Rhino-Laryngology, 2012, 269(2): 615-621.

DOI：10.1007/s00405-011-1615-x

• Sinonasal cancer
• Treatment
• Neck dissection
• Recurrence
• Histopathology

Sinonasal cancer is still a somewhat controversial entity because most series are single-center studies. The aim of this study was to give more accurate and generalisable information about treatment of the neck and prognosis of sinonasal cancer. Retrospective, population-based, multicentre study. Altogether 244 patients diagnosed in 1990-2004 were evaluated. The 3- and 5-year disease-specific survival (DSS) rates after treatment with curative intent were 68 and 57%, respectively. Regional status at the time of the diagnosis (P %26lt; 0.001, log rank) and local recurrence (P = 0.02, log rank) during the follow-up had a statistically significant effect on DSS. Initially 13% of the patients were diagnosed with neck metastasis. The proportion of regional recurrences during the follow-up was 9%, but it did not have a statistically significant impact on DSS (P = 0.68, log rank). Histopathology had no statistically significant impact on survival in this material of 244 patients. In conclusion, routine elective neck treatment of all sinonasal cancer patients is not recommended, but the importance of the treatment of the primary location is emphasised.

• 出版日期2012-2