Acute virulent infection with feline immunodeficiency virus (FIV) results in lymphomagenesis via an indirect mechanism

作者：Magden Elizabeth; Miller Craig; MacMillan Martha; Bielefeldt Ohmann Helle; Avery Anne; Quackenbush Sandra L; VandeWoude Sue^*

来源：Virology, 2013, 436(2): 284-294.

DOI：10.1016/j.virol.2012.12.003

• Feline immunodeficiency virus
• FIV
• Neoplasia
• Lymphoma
• Tumorigenesis
• Lymphomagenesis

Four cats (24%) experimentally infected with FIV unexpectedly developed neoplastic changes within four months of inoculation. While FIV has previously been associated with neoplasia, the rapidity and high attack rate seen here is highly unusual. PCR for antigen receptor rearrangements (PARR) detected clonally rearranged T cells in two animals diagnosed with B cell follicular lymphoma by classical means. All cats were negative for feline leukemia virus; gamma-herpesvirus DNA was not amplified using degenerate primers. FIV proviral load in neoplastic tissue was two orders of magnitude lower than in the periphery, lower in neoplastic vs non-neoplastic lymph node, and clonal integration was not detected. We hypothesize that neoplasia was secondary to FIV immune dysregulation, and show that PARR can augment our capacity to phenotype these tumors and distinguish follicular hyperplasia from lymphoma. Age of exposure and relative virulence of the inoculum likely contributed to this unusual presentation of FIV infection.

• 出版日期2013-2-20