Arterial stiffness and central hemodynamics in apparently healthy adults with impaired glucose regulation or high-normal blood pressure

作者：Bian, Suyan; Ye, Ping^*; Luo, Leiming; Wu, Hongmei; Xiao, Wenkai; Qi, Liping; Yu, Hepeng

来源：Healthmed, 2012, 6(7): 2314-2324.

• atherosclerosis
• hypertension
• diabetes
• arterial stiffness
• epidemiology

Aims: To compare the impact of high normal blood pressure (HNBP) and/or impaired glucose regulation (IGR) on arterial stiffness and central hemodynamics in general Chinese adults.
Methods: A random sample of 266 apparently healthy subjects aged 19 to 82 years with HNBP and/or IGR was examined in a cross-sectional study. Regional arterial stiffness was assessed by non-invasively measuring carotid-femoral (PWVc-f) and carotid-radial pulse wave velocity (PWVc-r). Central blood pressure and heart rate corrected augmentation index (AIx-75) were estimated by pulse wave analysis.
Results: Individuals with IGR (n = 145) had lower brachial SBP and pulse pressure (PP), but higher central SBP, PP, PWVc-f, and AIx-75 as compared with the HNBP population (n = 98). The HNBP + IGR group (n = 23) had the highest plasma high sensitivity C-reactive protein levels among the three groups. Subjects with HNBP + IGR had higher PWVc-f and AIx-75 than the HNBP population, but did not differ when compared with the IGR group. Correlation and multivariate stepwise regression analyses revealed that 2 h BG, but not FBG, was independently associated with PWVc-f; central SBP, but not brachial SBP, was an independent predictor for both PWVc-f and AIx-75. Blood glucose level and blood pressure showed no significant correlation with PWVc-r.
Conclusions: IGR preferentially deteriorates central over peripheral hemodynamics and core arterial stiffness. Postprandial glucose and central SBP could be reliable indicators of large artery stiffening. The presence of HNBP and IGR synergistically increases the severity of inflammation and deteriorates peripheral hemodynamics.

• 出版日期2012
• 单位中国人民解放军总医院