A sensing approach for dopamine determination by boronic acid-functionalized molecularly imprinted graphene quantum dots composite

作者：Zhou, Xi; Gao, Xuexia; Song, Fengyan; Wang, Chunpeng; Chu, Fuxiang^*; Wu, Shishan^*

来源：Applied Surface Science, 2017, 423: 810-816.

DOI：10.1016/j.apsusc.2017.06.199

• Graphene quantum dots
• Molecularly imprinted polymers
• DA
• Fluorescent
• Sensor

A novel fluorescence sensor was developed for dopamine (DA) determination based on molecularly imprinted graphene quantum dots and poly(indolylboronic acid) composite (MIPs@ PIn-BAc/GQDs). When the DA is added to the system, it leads to an aggregation and fluorescence quenching of the MIPs@ PIn-BAc/GQDs because of the covalent binding between the catechol group of DA and boronic acid. Such fluorescence behaviors are used for well testing DA in a range from 5 x 10(-9) to 1.2 x 10(-6) M with the detection limit of 2.5 x 10(-9) M. Furthermore, the prepared sensors could well against the interferences from various biomolecules and be successfully used for the assay of DA in human biological samples, exhibiting excellent specificity. It is believed that the prepared MIPs@ PIn-BAc/GQDs hold great promise as a practical platform that can monitor DA level change.

• 出版日期2017-11-30
• 单位江苏省建筑科学研究院有限公司; 南京大学; 中国林业科学研究院林产化学工业研究所