Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate

作者：Islam Rafiqul; Anzai Naohiko^*; Ahmed Nesar; Ellapan Babu; Jin Chun Ji; Srivastava Sunena; Miura Daisaku; Fukutomi Toshiyuki; Kanai Yoshikatsu; Endou Hitoshi

来源：Journal of Pharmacological Sciences, 2008, 106(3): 525-528.

DOI：10.1254/jphs.SC0070291

• propionate
• short chain fatty acid
• organic anion transporter

In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport Substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [H-3]PGE(2) transport was inhibited by three- to five-carbon SCFAs (C3 to C5). Among the SCFAs tested, propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner. Since propionate is a potent glucogenic compound, Oat2 may be involved in the regulation of cellular metabolism through the transport of these metabolites in the kidneys and the liver.

• 出版日期2008-3