Use of miRNAs as Biomarkers in Sepsis

作者：Dumache Raluca; Rogobete Alexandru Florin; Bedreag Ovidiu Horea; Sarandan Mirela; Cradigati Alina Carmen; Papurica Marius; Dumbuleu Corina Maria; Nartita Radu; Sandesc Dorel

来源：Analytical Cellular Pathology, 2015, 2015: 1-9.

DOI：10.1155/2015/186716

<jats:p>Sepsis is one of the most common causes of death in critical patients. Severe generalized inflammation, infections, and severe physiological imbalances significantly decrease the survival rate with more than 50%. Moreover, monitoring, evaluation, and therapy management often become extremely difficult for the clinician in this type of patients. Current methods of diagnosing sepsis vary based especially on the determination of biochemical-humoral markers, such as cytokines, components of the complement, and proinflammatory and anti-inflammatory compounds. Recent studies highlight the use of new biomarkers for sepsis, namely, miRNAs. miRNAs belong to a class of small, noncoding RNAs with an approximate content of 19–23 nucleotides. Following biochemical and physiological imbalances, the expression of miRNAs in blood or other body fluids changes significantly. Moreover, its stability, specificity, and selectivity make miRNAs ideal candidates for sepsis biomarkers. In conclusion, we can affirm that stable species of circulating miRNAs represent potential biomarkers for monitoring the evolution of sepsis.</jats:p>

• 出版日期2015