Association between ischemia-modified albumin, homocysteine, vitamin B-12 and folic acid in patients with severe sepsis

作者：Erdem Said Sami; Yerlikaya Fatma Humeyra^*; Cicekler Humeyra; Gul Mehmet

来源：Clinical Chemistry and Laboratory Medicine, 2012, 50(8): 1417-1421.

DOI：10.1515/cclm-2011-0794

• folic acid
• homocysteine
• ischemia-modified albumin
• sepsis
• vitamin B-12

Background: The aim of the present study was to investigate scrum ischemia-modified albumin (IMA), homocysteine, malondialdehyde (MDA), vitamin B-12 and folic acid levels in patients with severe sepsis, compared to healthy control subjects. Also, we examined associations of these parameters with high-sensitivity C-reactive protein (hsCRP) in patients with severe sepsis and healthy control subjects.
Methods: This study was performed on 71 (40 male, 31 female) patients with severe sepsis aged 18-65 years and 70 (34 male, 36 female) healthy control subjects aged 18-65 years. Samples of patients were obtained at study entry within 24 h of onset of severe sepsis.
Results: Serum IMA, homocysteine and MDA levels of the patients with severe sepsis were significantly higher than those of the healthy control subjects (p<0.0 I for IMA and homocysteine, and p<0.001 for MDA). There was no significant difference between serum vitamin B12 and folic acid levels of the groups. Serum hsCRP levels were positively correlated with IMA (p<0.01) and MDA (p<0.01) in the patients with severe sepsis.
Conclusions: Our findings show that IMA may be useful as a prognostic biomarker because it can indicate the severity of illness in patients with sepsis.

• 出版日期2012