PAI: Predicting adenosine to inosine editing sites by using pseudo nucleotide compositions

作者：Chen, Wei^*; Feng, Pengmian; Ding, Hui; Lin, Hao^*

来源：Scientific Reports, 2016, 6(1): 35123.

DOI：10.1038/srep35123

• SEQUENCE-BASED PREDICTOR
• WEB SERVER
• ACCURATE IDENTIFICATION
• RNA
• DNA
• PSEKNC
• MODES
• PACKAGE

The adenosine to inosine (A-to-I) editing is the most prevalent kind of RNA editing and involves in many biological processes. Accurate identification of A-to-I editing site is invaluable for better understanding its biological functions. Due to the limitations of experimental methods, in the present study, a support vector machine based-model, called PAI, is proposed to identify A-to-I editing site in D. melanogaster. In this model, RNA sequences are encoded by "pseudo dinucleotide composition" into which six RNA physiochemical properties were incorporated. PAI achieves promising performances in jackknife test and independent dataset test, indicating that it holds very high potential to become a useful tool for identifying A-to-I editing site. For the convenience of experimental scientists, a web-server was constructed for PAI and it is freely accessible at http://lin.uestc.edu.cn/server/PAI.

• 出版日期2016-10-11
• 单位中国科学技术大学; 电子科技大学