Neutrophil: lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

作者：Guo, Xiaoyan; Zhang, Shu; Zhang, Qing; Liu, Li; Wu, Hongmei; Du, Huanmin; Shi, Hongbin; Wang, Chongjin; Xia, Yang; Liu, Xing; Li, Chunlei; Sun, Shaomei; Wang, Xing; Zhou, Ming; Huang, Guowei; Jia, Qiyu; Zhao, Honglin; Song, Kun; Niu, Kaijun^*

来源：European Journal of Endocrinology, 2015, 173(2): 217-225.

DOI：10.1530/EJE-15-0176

• IMPAIRED FASTING GLUCOSE
• ACUTE-PHASE PROTEINS
• INSULIN-RESISTANCE
• FOLLOW-UP
• SUBCLINICAL INFLAMMATION
• ATHEROSCLEROSIS RISK
• CELL COUNT
• TNF-ALPHA
• PREVALENCE
• MELLITUS

Aim: It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil: lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship between NLR and T2D. In order to evaluate how NLR is related to T2D, we designed a large-scale cross-sectional and prospective cohort study in an adult population. @@@ Subjects and methods: Participants were recruited from the Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n=87 686) and a prospective (n=38 074) assessment were performed. Participants without a history of T2D were followed up for similar to 6 years (with a median follow-up of 2.7 years). Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the quintiles of NLR and T2D (covariates: age, sex, BMI, smoking status, drinking status, hypertension, hyperlipidemia, and family history of cardiovascular disease, hypertension, hyperlipidemia, or diabetes). @@@ Results: The prevalence and incidence of T2D were 4.9% and 6.8/1000 person-years respectively. The adjusted odds ratio and hazard ratio (95% CI) of the highest NLR quintile were 1.34 (1.21, 1.49) and 1.39 (1.09, 1.78) (both P for trend <0.01) respectively as compared to the lowest quintile of NLR. Leukocyte, neutrophil, and lymphocyte counts do not significantly predict the eventual development of T2D. @@@ Conclusion: The present study demonstrates that NLR is related to the prevalence and incidence of T2D, and it suggests that NLR may be an efficient and accurate prognostic biomarker for T2D.

• 出版日期2015-8
• 单位天津医科大学