科研之友
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摘要
Objectives: Blood donors in Canada have been tested for Human T-Cell Lymphotropic Virus (HTLV) since 1990. We report the epidemiology, risk factors and lookback/traceback of HTLV-positive donors/recipients. %26lt;br%26gt;Methods: The annual HTLV rate was calculated from 1990 to 2010. Residual risk was estimated as the product of incidence and window period. Twenty-nine HTLV-positive donors and 116 matched controls (ratio 1:4) were interviewed about risk factors. For HTLV-positive donations, lookback investigations involved identification of all previous donations, and attempting to locate and test recipients. Traceback was initiated when transfusion transmission was queried for HTLV-positive blood recipients. All donors of products that the recipient received were identified, with an attempt to locate and test them. %26lt;br%26gt;Results: The HTLV rate decreased from 9 center dot 35 per 100000 donations in 1990 to 1 center dot 11 in 2010. The residual risk of infection was 1 in 7 center dot 6 million donations. In logistic regression birth overseas (OR 18 center dot 7), history of sexually transmitted diseases (OR 32 center dot 9), sex with unknown background (OR 5 center dot 4) and blood transfusion (OR 8 center dot 9) were significant predictors. In the lookback study, of 109 HTLV-positive donors, 508 components were transfused, of whom 147 recipients were tested and 18 (12%) were positive. All were transfused prior to the implementation of donor testing. Twenty-three traceback investigations were requested involving 324 transfused untested products,of whom 219 (67 center dot 6%) of donors were tested and 13 (6%) were positive for HTLV. %26lt;br%26gt;Conclusions: With testing of the blood supply, the risk from HTLV is very low and while most HTLV-positive donors have risk factors, deferrable risk is rare.
- 出版日期2013-10
