Assessing the Usefulness of F-18-fluorodeoxyglucose PET-CT Scan After Stereotactic Body Radiotherapy for Early-Stage Non-small Cell Lung Cancer

作者：Pastis Nicholas J Jr^*; Greer Travis J; Tanner Nichole T; Wahlquist Amy E; Gordon Leonie L; Sharma Anand K; Koch Nicholas C; Silvestri Gerard A

来源：Chest, 2014, 146(2): 406-411.

DOI：10.1378/chest.13-2281

BACKGROUND: Although stereotactic body radiation therapy (SBRT) is an established treatment option for early-stage lung cancer, there are no guidelines for reassessing patients for local treatment failure or intrathoracic recurrence after treatment. This study reports the sensitivity, specificity, and positive and negative predictive values for F-18-fluorodeoxyglucose (FDG) PET-CT scanning when used to evaluate patients aft er SBRT. %26lt;br%26gt;METHODS: Charts were reviewed of all patients who received SBRT and a subsequent FDG PET-CT scan at a university hospital over a 5-year period. Pretreatment and 3-month post-treatment tumor characteristics on PET-CT scan and outcome data (adverse events from SBRT, need for repeat biopsy, rate of local treatment failure and recurrent disease, and all-cause mortality) were recorded. %26lt;br%26gt;RESULTS: Eighty-eight patients were included in the study. Fourteen percent of patients (12 of 88) had positive 3-month PET scans. Of the positive results, 67% (eight of 12) were true positives. Eighty-six percent (76 of 88 patients) had negative 3-month FDG PET-CT scans, with 89% (68 of 76) true negatives. FDG PET-CT scan performed 3 months aft er SBRT for non-small cell lung cancer (NSCLC) had a sensitivity of 50% (95% CI, 0.26-0.75), a specificity of 94% (95% CI, 0.89-1.0), a positive predictive value of 67% (95% CI, 0.4-0.93), and a negative predictive value of 89% (95% CI, 0.83-0.96). %26lt;br%26gt;CONCLUSIONS: FDG PET-CT scan 3 months aft er treatment of NSCLC with SBRT was a specific but insensitive test for the detection of recurrence or treatment failure. Serial CT scans should be used for early surveillance following SBRT, whereas FDG PET-CT scans should be reserved to define suspected metastatic disease or to evaluate new abnormalities on CT scan, or for possible reassessment later in the follow-up period aft er radiation-related inflammation subsides.

• 出版日期2014-8