科研之友
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摘要
A new safe and convenient transformation has been developed. In the presence of cesium formate in dry MeOH solution, alpha-haloketones underwent direct conversion reaction to afford alpha-hydroxyketone in excellent yields. Furthermore, this methodology can be extended and applied in 2-chloro-N-(1,3-diphenyl-1H-pyrazol-5-yl)acetamide, 2-chloro-N-(2,6-dimethylphen-yl)acetamide, 1-(bromomethylsulfonyl)benzene, and N-(bromomethyl)phthalimide to give the corresponding products in moderate to excellent yields.
- 出版日期2009-10-1
- 单位中国医科大学
