Stereoselective Synthesis of Sialylated Tumor-Associated Glycosylamino Acids

作者:Corcilius Leo; Payne Richard J*
来源:Organic Letters, 2013, 15(22): 5794-5797.
DOI:10.1021/ol402845e

摘要

Suitably protected sialyl T-N and 2,6-sialyl T tumor-associated carbohydrate antigen-derived amino acids have been prepared stereoselectively using an oxazolidinone-derived sialoside donor. These glycosylamino acids can be employed directly in the solid-phase synthesis of glycopeptides, as demonstrated by the efficient preparation of tumor-associated MUC1 glycopeptide fragments.

  • 出版日期2013-11-15