科研之友
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摘要
Objective: Many previous studies demonstrated that the hypoxia led to the abnormal spontaneous brain activity, whereas the intrinsic brain activity changes in asthma patients remain unknown. The study aimed to evaluate the alterations of spontaneous brain activity in asthma patients using amplitude of low-frequency fluctuation (ALFF) method and its relationships with clinical features. Methods: A total of 27 patienits with asthma (17 males and 10 females) and 27 healthy controls (HCs) (17 males and 10 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was applied to assess spontaneous brain activity changes. Patients with asthma were distinguished from HCs by receiver operating characteristic (ROC) curve. The relationships between the mean ALFF signal values in many brain regions and clinical features in asthma patients were calculated by pearson correlation analysis. Results: Compared with HCs, the asthma patients had significantly lower ALFF in the bilateral cerebellum anterior lobe/brainstem/thalamus/putamen/posterior cingulate cortex/middle cingulate cortex/lingual gyrus (BA 18, 19, 23, 30) and left middle occipital gyrus (BA 18); In contract, the asthma patients showed higher ALFF values in the left cerebellum posterior lobe, left middle temporal gyrus (BA 20, 37), right middle temporal gyrus (BA 20, 21), left superior temporal gyrus (BA 53) and bilateral superior frontal gyrus/precentral gyrus (BA 4, 6, 8, 9). However, no relationship was found between the mean ALFF signal values of the different brain areas and the clinical manifestations in asthma patients. Conclusion: We demonstrated that asthma patients had abnormal spontaneous activities in many brain regions related to respiratory control and emotion control function, which might provide some useful informations to explain the neural mechanisms of clinical features including hypoxia, dyspnea and depression in asthma patients.
