Maternal, umbilical arterial and umbilical venous 25-hydroxyvitamin D and adipocytokine concentrations in pregnancies with and without gestational diabetes

作者：McManus Ruth^*; Summers Kelly; de Vrijer Barbra; Cohen Nicole; Thompson Alexandra; Giroux Isabelle

来源：Clinical Endocrinology, 2014, 80(5): 635-641.

DOI：10.1111/cen.12325

ObjectiveGestational diabetes mellitus (GDM) has been associated with inflammation as well as Vitamin D insufficiency. While Vitamin D has anti-inflammatory properties, relationships between Vitamin D and inflammatory markers remain unexplored in GDM. Therefore, this case--control study investigated adipocytokine and Vitamin D [25(OH)D] concentrations and correlations in GDM and control women, as well as their neonates.
Design/Participants/Measurementsseventy-three women participated: 36 GDM and 37 controls. Maternal samples were drawn at 31weeks. Umbilical arterial and venous samples were collected at birth. 25(OH)D and adipocytokine concentrations were compared for GDM vs control maternal, umbilical arterial and venous samples. Correlations were explored between biochemical results, maternal and neonatal demographics.
ResultsCompared with age- and weight-matched control participants, GDM women had significantly lower concentrations of 25(OH)D (773243 vs 932 +/- 192nm/l; P=0009); adiponectin (175 +/- 118 vs 341 +/- 203g/ml, P<0001); resistin (254 +/- 91 vs 319 +/- 121ng/ml, P=0045); and plasminogen activator inhibitor-1 (PAI-1) 139 +/- 100 vs 210 +/- 126ng/ml, P=0038), while delivering 1week earlier (382 +/- 12 vs 395 +/- 09weeks, P<0001). GDM maternal 25(OH)D concentrations positively correlated with PAI-1, IL-8 and TNF- concentrations. Umbilical 25(OH)D concentrations were not significantly different in GDM vs control offspring, whereas adiponectin, resistin and PAI-1 concentrations were significantly lower in GDM offspring.
ConclusionsGDM women had lower 25(OH)D concentrations than controls, while neonatal umbilical concentrations of 25(OH)D did not differ. GDM maternal and GDM offspring had lower adiponectin, resistin and PAI-1 concentrations compared with controls. Results suggest that both GDM women and their offspring demonstrate abnormal adipocytokine patterns.

• 出版日期2014-5