Post-transplant Renal Function and Cardiovascular Events Are Closely Associated With the Aortic Calcification Index in Renal Transplant Recipients

作者：Imanishi K; Hatakeyama S^*; Yamamoto H; Okamoto A; Imai A; Yoneyama T; Hashimoto Y; Koie T; Fujita T; Murakami R; Saitoh H; Funyu T; Narumi S; Ohyama C

来源：Transplantation Proceedings, 2014, 46(2): 484-488.

DOI：10.1016/j.transproceed.2013.09.039

Introduction. The aortic calcification index (ACT) is reported to be closely associated with renal dysfunction and cardiovascular events; however, its implication in renal transplant recipients has not been well examined. In this study, we investigated the relationship between pretransplant ACI, ACI progression, post-transplant renal function, and post-transplant cardiovascular events in renal transplant recipients. %26lt;br%26gt;Patients and methods. The study from June 1996 to Jan 2012 included 61 renal transplant recipients (living donors, 47; cadaveric donors, 14). The median follow-up period was 60 months. ACT was quantitatively measured on abdominal computed tomography. The relationship between age, dialysis period, estimated glomerular filtration rate (eGFR), and pre- and post-transplant ACT was longitudinally evaluated. Risk factors for post-transplant ACI progression were determined by logistic regression analysis. Patient background and the incidence of post-transplant cardiovascular events were also assessed. %26lt;br%26gt;Results. The pretransplant ACI (median 4.2%) significantly correlated with age at transplant, dialysis period, and diabetes mellitus. ACT gradually increased up to 2.8 times at 10 years after transplantation. Post-transplant eGFR significantly correlated with ACT progression in patients with chronic kidney disease of stage %26gt;= 3. Logistic regression analyses showed that age at transplantation, post-transplant period, cadaveric donors, and post-transplant chronic kidney disease stage 3 were risk factors for post-transplant ACI progression. The pretransplant ACT was higher (median 66%) in 3 patients who experienced post-transplant cardiovascular events. %26lt;br%26gt;Conclusions. ACI progression closely correlates with age and post-transplant renal function. A high pretransplant ACT is a risk factor for post-transplant cardiovascular events in renal transplant recipients.

• 出版日期2014-3