Acute cardiovascular effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine in human subjects: A placebo-controlled, double-blind study

作者：Ratamess Nicholas A.^*; Bush Jill A.; Stohs Sidney J.; Ellis Nicole L.; Vought Ira T.; O'Grady Elizabeth A.; Kuper Jeremy D.; Hasan Saif B.; Kang Jie; Faigenbaum Avery D.

来源：Phytotherapy Research, 2018, 32(1): 94-102.

DOI：10.1002/ptr.5953

• blood pressure
• caffeine
• Citrus aurantium
• heart rate
• mean arterial pressure
• p-synephrine

The purpose was to examine cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects were given (in double-blind manner) either 103mg of p-synephrine (S), 233mg of caffeine +104mg of p-synephrine (LC+S), 240mg of caffeine (LC), 337mg of caffeine +46mg of p-synephrine (HC+S), 325mg of caffeine (HC), or a placebo. The subjects sat quietly for 3hr while heart rate (HR) and blood pressure were measured. Only HC+S and HC significantly increased mean systolic blood pressure (SBP) during the second hour and tended to increase mean SBP during the third hour. Mean diastolic blood pressure in S was significantly lower than the other trials during the first and second hours, and mean arterial pressure was significantly lower in S compared to the LC, LC+S, HC, and HC+S trials. No differences were observed in HR. Consumption of p-synephrine may acutely reduce diastolic blood pressure and mean arterial pressure and not affect SBP or HR during quiet sitting. The addition of p-synephrine to caffeine did not augment SBP or HR indicating that consumption of up to 104mg of p-synephrine does not induce cardiovascular stress during quiet sitting.

• 出版日期2018-1