A New Pilot Quadruple Therapy for Helicobacter pylori Treatment Failure using Lansoprazole, Bismuth Potassium Citrate, Levofloxacin, and Furazolidone

作者：Zhang, Zhiqiang; Xia, Yu; Yao, Ping; Yang, Tao; Li, Xiujuan^*

来源：Latin American Journal of Pharmacy, 2015, 34(1): 196-200.

• Eradication rate
• Helicobacter pylori
• Quadruple regimens
• Rescue regimens

Helicobacter pylori treatment failure is an emergent problem in clinical practice. This study aimed to evaluate the efficacy of a quadruple regimen with lansoprazole, bismuth potassium citrate, levofloxacin, and furazolidone as a 'rescue' treatment for H. pylori eradication. Patients with at least 1 incident of H. pylori eradication failure were included and underwent rescue therapy with levofloxacin (500 mg once daily), furazolidone (100 mg twice daily), bismuth potassium citrate (220 mg twice daily), and lansoprazole (30 mg twice daily) administered for 7 days. Follow-up C-14-urea breath tests were performed 6-8 weeks after the end of treatment to assess treatment response. One hundred forty-six patients were included in the study. Eradication rates according to intention-to-treat and per-protocol analyses were 80.1% (95% confidence intervals: 73.7-86.6%) and 83.6% (95% confidence intervals: 77.4-89.7%), respectively. Mild adverse events were reported. With the limitations of a pilot study, these results suggest that the 7-day quadruple regimen constituted a well-tolerated, inexpensive, and effective alternative when used as a rescue therapy in patients infected with H. pylori.

• 出版日期2015
• 单位新疆医科大学