Antioxidant and Anti-inflammatory Active Dihydrobenzofuran Neolignans from the Seeds of Prunus tomentosa

作者：Liu, Qing-Bo; Huang, Xiao-Xiao; Bai, Ming; Chang, Xiao-Bing; Yan, Xin-Jia; Zhu, Tao; Zhao, Wei; Peng, Ying; Song, Shao-Jiang^*

来源：Journal of Agricultural and Food Chemistry, 2014, 62(31): 7796-7803.

DOI：10.1021/jf502171z

• Prunus tomentosa
• food byproduct
• seeds
• neolignans
• antioxidant
• anti-inflammatory

Prunus tomentosa seeds were researched for antioxidant and anti-inflammatory constituents. By activity-guided fractionation of P. tomentosa seed extract, six new dihydrobenzofuran neolignans, prunustosanans Al-IV (1-4) and prunustosanansides AI and AII (5 and 6), together with 10 known compounds (7-16) were isolated from bioactive fraction. The structures were determined by spectroscopic analyses, especially NMR, HRESIMS, and CD spectra. The antioxidant activity was greatest for 5, 10, and 12 against DPPH radical and for 8, 9, and 13 against ABTS radical. Moreover, compounds 7 and 11 exhibited much stronger inhibitory activity on nitric oxide (NO) production in murine microglia BV-2 compared with positive control minocycline (IC50 = 19.7 +/- 1.5 mu M). The results show that P. tomentosa seeds can be regarded as a potential source of antioxidants and inflammation inhibitors.

• 出版日期2014-8-6
• 单位沈阳药科大学