Development and regulation of ROR gamma t(+) innate lymphoid cells

作者：Cording Sascha; Medvedovic Jasna; Cherrier Marie; Eberl Gerard^*

来源：FEBS LETTERS, 2014, 588(22): 4176-4181.

DOI：10.1016/j.febslet.2014.03.034

• Innate lymphoid cells
• Mucosal immunity
• ROR gamma t
• IL-22

ROR gamma t(+) innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL-22, IL-17A and LT alpha 1 beta 2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation.

• 出版日期2014-11-17