A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction

作者：Ye, Rui Rong; Tan, Cai Ping^*; Lin, Yan Nan; Ji, Liang Nian; Mao, Zong Wan

来源：Chemical communications, 2015, 51(39): 8353-8356.

DOI：10.1039/c5cc02354h

In this report, we designed a histone deacetylase-targeted phosphorescent Re(I) complex ReLMito. Colocalization studies suggested that ReLMito could specially localize to mitochondria. We also demonstrated that ReLMito could induce paraptosis in cancer cells. These features endowed the complex with potential to induce and monitor mitochondrial morphological changes during the paraptosis simultaneously.

• 出版日期2015
• 单位中山大学