Micronucleated Erythrocytes in Newborn Rats Exposed to Raltegravir Placental Transfer

作者：Miriam Torres Mendoza Blanca; Elizabeth Coronado Medina Damharis; Claudia Gomez Meda Belinda; Vazquez Valls Eduardo; Lourdes Zamora Perez Ana; de Lourdes Lemus Varela Maria; Moises Zuniga Gonzalez Guillermo

来源：Biomed Research International, 2014, 2014: 851820.

DOI：10.1155/2014/851820

The use of raltegravir in treating HIV/AIDS has been proposed due to its effectiveness in suppressing high loads of HIV RNA in pregnant women, thus preventing infection of the fetus. However, administration of raltegravir during pregnancy produces a compound which is transferred to high concentrations to the offspring. The objective of this study is to evaluate the transplacental genotoxic effect of raltegravir in newborn rats. We evaluated the number of micronucleated erythrocytes (MNE), micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) in the peripheral blood samples of the offspring of Wistar rats treated 6 days before birth with oral administration of raltegravir. The animals were randomly assigned to five groups as follows: raltegravir at doses of 15, 30, or 60mg/day, cyclophosphamide 10mg/kg (positive control), or 0.5ml of sterile water (negative control). In addition, the effect of these drugs on the weight and height of newborns was assessed. There were no differences in the number of MNE, MNPCE, and PCE, and a slight decrease in the weight and height was observed in the offspring of the rat mothers treated with raltegravir. Genotoxicity studies are required in pregnant women to determine the risk of using raltegravir to the fetuses.

• 出版日期2014