Anti-HIV, antimycobacterial and antimicrobial studies of newly synthesized 1,2,4-triazole clubbed benzothiazoles

作者：Patel Navin B^*; Khan Imran H; Pannecouque Christophe; De Clercq Erik

来源：Medicinal Chemistry Research, 2013, 22(3): 1320-1329.

DOI：10.1007/s00044-012-0129-4

• 1,2,4-Triazole
• Benzothiazoles
• Anti-HIV activity
• Antimycobaterial activity
• Antimicrobial activity

In an attempt to synthesize pharmacologically active molecules, we report here the synthesis and in vitro anti-HIV, antimycobacterial and antimicrobial activity of various series of 3-(3-pyridyl)-5-(4-substitutedphenyl)-4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole. The anti-HIV activity of the title compounds was evaluated as selective human immunodeficiency virus type-1 and -2 (HIV-1, HIV-2 RT) inhibitors, antitubercular activity against H(37)Rv using Lowenstein-Jensen agar method and antimicrobial activity against certain bacterial and fungal strains using the broth microdilution method. The synthesized compounds were characterized by FTIR,H-1-NMR,C-13-NMR and mass spectral data together with elemental analysis.

• 出版日期2013-3
• 单位河北医科大学