A Water-Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans (Fries) and Its Anti-Malarial Activity

作者：Bi, Hongtao; Han, Han; Li, Zonghong; Ni, Weihua; Chen, Yan; Zhu, Jingjing; Gao, Tingting; Hao, Miao; Zhou, Yifa^*

来源：Evidence-Based Complementary and Alternative Medicine, 2011, 2011: 1-12.

DOI：10.1093/ecam/neq070

• CELL-WALL POLYSACCHARIDES
• IMMUNOMODULATORY ACTIVITY
• ARTEMISININ
• MALARIA
• COMPONENTS
• EXTRACT
• FUNGUS

A water-soluble polysaccharide (BIWS-4b) was purified from the fruit bodies of Bulgaria inquinans (Fries). It is composed of mannose (27.2%), glucose (15.5%) and galactose (57.3%). Its molecular weight was estimated to be 7.4 kDa (polydispersity index, Mw/Mn: 1.35). Structural analyses indicated that BIWS-4b mainly contains (1 -> 6)-linked, (1 -> 5)-linked and (1 -> 5,6)-linked beta-Galf units; (1 -> 4)-linked and non-reducing terminal beta-Glcp units; and (1 -> 2)-linked, (1 -> 6)-linked, (1 -> 2,6)-linked and non-reducing terminal alpha-Manp units. When examined by the 4-day method and in a prophylactic assay in mice, BIWS-4b exhibited markedly suppressive activity against malaria while enhancing the activity of artesunate. Immunological tests indicated that BIWS-4b significantly enhanced macrophage phagocytosis and splenic lymphocyte proliferation in malaria-bearing mice and normal mice. The anti-malarial activity of BIWS-4b might be intermediated by enhancing immune competence and restoring artesunate-suppressed immune function. Thus, BIWS-4b is a potential adjuvant of anti-malaria drugs.

• 出版日期2011
• 单位东北师范大学